A young man and woman, Vincent (Lucas Till) and Victoria (Kiersey Clemons), cross paths on Halloween night. As a result of their meeting, they and Victoria's boss' dog, Ichabod, find themselves in a "magical adventure of personal discovery" at the This Place Hotel, located at 777 Jackson Street. They meet the bellhop chimp Bubbles (Brad Garrett), the scarecrow groundskeeper Hay Man (Jim Parsons), spider security guard Generalissimo Meriweather (Alan Cumming), and cat mad scientist Franklin Stein (Diedrich Bader) who they join in stopping the tyrannical witch Conformity (Lucy Liu) from getting rid of music and dancing.
The story culminates in a dance finale featuring an animated version of Michael Jackson himself (voiced using his music and archival recordings).